Helica · Pharmacogenomics, plainly stated

The drugs your liver
can’t metabolize.

Helica reads the DNA file you already have and tells you which prescriptions to flag for your doctor. Cited. Conversational. Reanalyzed every quarter.

Action recommended
CPIC A

CYP2C19

*2/*38

Intermediate metabolizer

Your CYP2C19 enzyme processes some drugs more slowly. The most common one to flag: clopidogrel (Plavix) — it may not work as well for you.

Affected medications

  • clopidogrel·
  • voriconazole·
  • citalopram·
  • escitalopram·
  • omeprazole
CPIC 2022 clopidogrel guidelineAldy 4.8 / PharmCAT 3.0.1

A real finding, on a real genome.

A pitch in three sentences

Most genome reports are a static dump you read once and file away.
Helica is a conversation with the file you already paid for.
And it’s reanalyzed every quarter, as the science evolves.

A worked example

Same data. Three voices. One genome.

We test every line of copy against this question: would Helica actually surface this for a real customer, in language they can use?

01 — The patient view

Plain English. Always.

“Your ABCG2 transporter is impaired. CPIC recommends limiting rosuvastatin to ≤20 mg/day.” Not poor function, not diplotype, not jargon you have to translate before you can act on it.

02 — The clinical view

The same data, formatted for a 7-minute visit.

Generate a one-page PDF for your prescriber on demand. Genotype, phenotype, CPIC level, affected medications, citation. Nothing else. Designed to be the first PGx document a primary-care physician actually reads.

Download the sample PDF

03 — The cited line

Every claim, linked.

The card shows the source — CPIC’s 2022 statin guideline — and the pipeline that called it: PharmCAT 3.0.1. Click through to the underlying paper. We don’t ask you to trust us. We ask you to verify us.

Action recommended
CPIC A

ABCG2

rs2231142 T/T

Poor function

Your ABCG2 transporter is impaired. CPIC recommends limiting rosuvastatin to ≤20 mg/day; consider an alternative statin if higher dose is required.

Affected medications

  • rosuvastatin

Why a subscription

13–22%

additional findings on the same genome over a few-year window — because the science around your variants changes constantly. We re-run your file every quarter and email you the diff.

PMC7338758 · Re-analysis of clinical exome sequencing data

What Helica covers

The full clinical depth of your file.

We don’t re-sequence. We read the file you already have at the depth the existing consumer products skipped.

  • 01PharmacogenomicsCPIC core panel·CYP2C19, CYP2D6, ABCG2, SLCO1B1, DPYD, TPMT and the rest of the level A/B gene set.
  • 02Carrier statusACMG SF v3.2·Common-variant carrier reporting on Standard; rare-variant + ACMG on Clinical.
  • 03Structural variantsAnnotSV·Credibility-tiered. The mile-long DRAGEN call list is filtered to the credible 11.
  • 04HLA fine-typingT1K · 4-digit·Five loci. The HLA-B *57:01 abacavir call you can't get from a chip array.
  • 05Polygenic riskPGS Catalog·Peer-reviewed only. Each PRS shipped with a 95% CI and the validating paper.
  • 06Traits~70 calls·Lightweight. Labeled as the lightweight findings they are. Not why you subscribe.
  • 07ReanalysisQuarterly·Built for quarterly diff alerts. New ClinVar reclass, new CPIC guidance — rolling out at launch.
  • 08AncestryFree tier·23andMe-comparable. We're not building an ancestry product; the report is a side effect.

Pricing

A monthly subscription, not a one-time test.

Reanalysis is the actual subscription value. Findings get reclassified. CPIC guidelines update. New PGx genes hit clinical-grade evidence. Your file gets re-run every quarter.

The product for most adults

Helica Standard

$29/ month

$24/mo billed annually

  • · Full PGx panel — every CPIC level A/B gene
  • · Carrier status (common variants)
  • · ~70 trait calls and basic polygenic risk
  • · Unlimited conversational chat, fully cited
  • · Quarterly reanalysis with diff alerts (rolling out at launch)
Start Standard

Free tier available at launch.

Free tier · No credit card

Upload the file you already have.
See two findings free.

Start with the file you already have. Two real findings on your own genome — a PGx flag and a carrier call — before you decide if it's worth subscribing.

Helica is informational and not a substitute for medical advice. Discuss any change to your medications with a licensed prescriber. Findings are based on validated, peer-reviewed sources, including CPIC, ClinVar, and the PGS Catalog. Polygenic risk scores are useful estimates, not diagnoses.